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Leukemia


Leukemia is a cancer of the blood in which there is a rapid and uncontrolled release of immature white blood cells called “blasts” into the blood stream.

The following is an excerpt from Chapter 1 of Alan and Cecilia’s inspirational new book, Climb Back from Cancer. It more fully explains the nature of the disease.

The nights before our next appointment passed interminably, the days not much faster. Finally, we were face to face again with Dr. Poon.

“I confirm a diagnosis of acute myeloid leukemia,” he said assuredly. “Without treatment, your prognosis is less than a year.”

The words seemed to hang in the air of the examining room like sinister vapors twisting weightlessly. They hardly registered in my brain. They simply hung, like a noose.

I looked over at Cecilia to see how she was taking the news. Incredibly, she was taking notes.

My mind shot out one question. I knew cancer treatment often involved intensive chemotherapy. That scared me. So I asked Dr. Poon, “What if I do nothing?”

His answer sticks with me to this day: “You’re screwed.”

Startled by the directness of the reply, I asked him what treatment options I had. He explained that with chemotherapy, the chances of putting the leukemia into remission were about seventy percent. The problem was remission could be only temporary. If we were able to put my cancer into remission and if a possible donor match could be found fast enough, I might be able to receive a bone marrow or adult blood cell transplant that might “cure” me of the disease. Still, that was a lot of “ifs.”

“So,” he asked, “is the cup half empty or is it half full, Alan? The choice is yours.”


“Is the cup half empty or is it half full? The choice is yours.”

– Dr. Man-Chiu Poon,
    Hematologist


Dr. Man-Chiu Poon, a kind and internationally respected blood specialist with decades of experience treating cancer, was not being insensitive by bluntly telling me how serious my situation was. On the contrary, he had quickly decided how best to communicate with a strong-willed patient and he had read me perfectly. He had chosen to be brutally honest -- and for good reason.

Acute leukemia is cancer of the blood. It is a potentially lethal condition during which there is a rapid and uncontrolled release of trillions of immature and ineffective white blood cells called “blasts” from the bone marrow into the blood stream. These blasts pour into the blood, quickly pushing aside all the healthy white blood cells used to combat disease, the red blood cells used to transport oxygen to the tissues and the platelets used to stop bleeding. A patient with acute leukemia can rapidly hemorrhage because of a low platelet count, die from infection due to ineffective white blood cells or get progressively weaker and weaker from anemia because of an insufficient number of oxygen-carrying red blood cells. Eighty-five percent of those diagnosed with the condition are dead within three years. Untreated, the disease is one hundred percent fatal. You cannot cut leukemia out with surgery or burn it out with radiation. Once the cancer is in your blood, it is in your whole body. Each year about 35,000 – about one in 10,000 North Americans -- are diagnosed with the disease. Now, I was one of them. 

Dr. Poon’s biopsy of my bone marrow had shown that a frightening ninety percent of the cells in my bone marrow, the main manufacturing plant for blood cells, and forty percent of the cells in my bloodstream, were blasts. If the number of blasts in my bloodstream increased much more, or if I hemorrhaged or developed an infection, it was over for me. Dr. Poon knew he had to get my attention. With his shoot-from-the-hip, no-holds-barred bedside manner, he earned my instant respect as a physician who had the guts to tell it like it was.

“We need to admit you and begin intensive, around-the-clock chemotherapy right away,” he said, his intense stare burning the severity of the situation into my stunned psyche. “Treatment will take at least four months. Would you like to begin Saturday?”

It was Thursday. With all due appreciation for Dr. Poon’s lightning-swift attention to my case, this was still happening too fast. Given more time, I might be able to get my mind around the fact I had cancer, but double-barreled chemotherapy of the magnitude he was talking about was another leap altogether, to say nothing of shutting down my business and my life for at least four months. Our time away in the mountains had helped us to consider our options, but nothing could have prepared us for this moment. I was overwhelmed.

I could not accept that I had cancer of the blood. I did not want to lose my hair or the contents of my stomach repeatedly. I did not want to start popping pills like corner-store candy, experience endless blood transfusions or endure innumerable invasive bone marrow biopsies. I did not want to lose my savings, my vocation or my self-identity. I did not want to lose control, or what I perceived as control, of my whole life as I had known it. Mostly, I did not want to die; I wanted to live.


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